In vitro effects of methotrexate

The in vitro effects of methotrexate on peripheral blood mononuclear cells: Modulation by methyl donors and spermidae. Studies in healthy volunteers and patients with rheumatoid arthritis. Inhibition of cytokine production by methotrexate. Relationship between genetic variants in the adenosine pathway and outcome of methotrexate treatment in patients with recent-onset rheumatoid arthritis. Adenosine A2A or A3 receptors are required for inhibition of inflammation by methotrexate and its analog MX-68. Reversal of the antiinflammatory effects of methotrexate by the nonselective adenosine receptor antagonists theophylline and caffeine: evidence that the antiinflammatory effects of methotrexate are mediated via multiple adenosine receptors in rat adjuvant arthritis.