Molecular therapeutics: Methotrexate and its mechanism of action. Methotrexate and sulfasalazine promote adenosine release by a mechanism that requires ecto-5'-nucleotidase-mediated conversion of adenine nucleotides. The effect of food on methotrexate absorption. Bioavailability of higher dose methotrexate comparing oral and subcutaneous administration in patients with rheumatoid arthritis. Why intramuscular methotrexate may be more efficacious than oral dosing in patients with rheumatoid arthritis.
Methotrexate therapy in rheumatoid arthritis: 15 years experience. Methotrexate: A perspective of its use in the treatment of rheumatic diseases. Effect of aminopterin in rheumatoid arthritis and psoriasis. Therapeutic suppression of tissue reactivity. Always seek the advice of your own physician or other qualified health care professional regarding any medical questions or conditions. The content on the UpToDate website is not intended nor recommended as a substitute for medical advice, diagnosis, or treatment. To continue reading this article you need to subscribe. Thus, any impairment of glomerular filtration rate will result in sustained serum levels of the drug that may induce bone marrow or other toxicities. MTX is primarily cleared via the kidneys, with 80 to 90 percent being excreted unchanged in the urine. This was illustrated in a pharmacokinetic analysis of 15 patients taking more than 25 mg/week of MTX ; the ratio of oral to subcutaneous absorption was decreased by approximately one-third.
